STX1B and KCNN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX1B	KCNN4
Description		syntaxin 1B	potassium calcium-activated channel subfamily N member 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Lamina Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Axon SNARE Complex Neuromuscular Junction Presynaptic Active Zone Membrane Presynapse	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Vesicle Ruffle Membrane Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	SNARE Binding Signaling Receptor Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Gene Expression Regulation Of Synaptic Vesicle Priming Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Synaptic Activity Spontaneous Neurotransmitter Secretion Negative Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Immune System Process Monoatomic Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Monoatomic Ion Transmembrane Transport Macropinocytosis Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Transport Protein Homotetramerization Establishment Of Localization In Cell Regulation Of Biological Quality Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions	Ca2+ activated K+ channels
Drugs			Clotrimazole Quinine Procaine Ritodrine Nitrendipine Miconazole Halothane Colforsin Trimebutine
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Dementia with Lewy bodies ( 29263008) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Juvenile myoclonic epilepsy ( 30531953) Low density lipoprotein cholesterol levels ( 32154731) Parkinson's disease ( 25064009 32201043) Psoriasis ( 25574825) Response to metformin (IC50) ( 28173075) Waist circumference ( 31453325) Waist circumference variance ( 31453325) Walking pace ( 33128006)	Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ABHD16A ACBD5 AQP6 BET1 EBP ERGIC3 FAM161B FAM209A FAM81A FBXO28 FGA GJA8 GPR152 KCNN4 MMGT1 NAPB SNAP23 SNAP29 SNAP47 SNCA STX2 STX4 STXBP1 TMEM167B TXLNA UBE2I UNC13B VAMP1 VAMP2 VAMP5	13 interacting genes: BIK CACNA1D CALM1 CNIH3 FXYD3 GPR152 JPH3 JPH4 PMP22 PRKAG1 RYR2 SLC30A2 STX1B
Entrez ID		112755	3783
HPRD ID		18126	04130
Ensembl ID		ENSG00000099365	ENSG00000104783
Uniprot IDs		P61266	O15554
PDB IDs			6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Syntaxin Binding Exocytosis Synaptic Vesicle Priming Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion SNARE Complex Assembly Secretion Secretion By Cell Organelle Fusion Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Vesicle Organization Membrane Organization Synaptic Vesicle Membrane Organization SNARE Binding Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Protein-containing Complex Organization Syntaxin-1 Binding Vesicle Docking Positive Regulation Of Protein Transport Protein-containing Complex Assembly Positive Regulation Of Protein Localization Positive Regulation Of Secretion By Cell Positive Regulation Of Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Exocytosis Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Transport Vesicle Cellular Component Assembly Regulated Exocytosis Cornified Envelope Assembly Neuronal Dense Core Vesicle Exocytosis Cellular Localization Presynapse Regulation Of Secretion By Cell Establishment Of Protein Localization Dense Core Granule Exocytosis Positive Regulation Of Transport Synaptic Vesicle Membrane	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Metal Ion Transport Calcium Ion Transport Into Cytosol Regulation Of Heart Contraction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Regulation Of Striated Muscle Contraction Regulation Of Blood Circulation Regulation Of System Process Metal Ion Transport Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium Ion Transmembrane Transport Regulation Of Transport Inorganic Ion Transmembrane Transport Calcium-mediated Signaling Membrane Regulation Of Muscle Contraction Junctional Membrane Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Membrane Potential Plasma Membrane Calcium Ion Transport Monoatomic Ion Transport Regulation Of Muscle System Process Detection Of Calcium Ion Inorganic Cation Transmembrane Transport Regulation Of Heart Rate Monoatomic Cation Transmembrane Transport Transmembrane Transport Smooth Endoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Cell Action Potential Protein Kinase Binding Cardiac Muscle Cell Action Potential Involved In Contraction Modulation Of Chemical Synaptic Transmission Cardiac Muscle Cell Action Potential Regulation Of Synaptic Plasticity Dendritic Shaft
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