PRSS23 and NIPBL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRSS23	NIPBL
Gene Name		protease, serine, 23	Nipped-B homolog (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Chromatin Nucleus Nucleoplasm SMC Loading Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding
	Biological Process	Proteolysis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Maintenance Positive Regulation Of Histone Deacetylation Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Cellular Response To X-ray
Pathways			Mitotic Telophase/Cytokinesis Cohesin Loading onto Chromatin Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: ACTG1 APP B2M CHP1 EFNA3 FXR1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDDC1 PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4	8 interactors: CBX3 CBX5 CDK6 DBN1 HINFP MAU2 PRSS23 SP100
Entrez ID		11098	25836
HPRD ID		07149	10560
Ensembl ID		ENSG00000150687	ENSG00000164190
Uniprot IDs		B4E2J3 O95084	Q6KC79
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Cell Differentiation Cellular Component Assembly Regulation Of Body Fluid Levels Organelle Organization Wound Healing Multicellular Organismal Development Generation Of Neurons Cell Activation Dendrite Development System Development Response To Stress Response To Wounding Neurogenesis Mating Behavior Nervous System Development Regulation Of Protein Localization Response To Stimulus Neuron Projection Development Cell Development Developmental Process Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Uncoating Of Virus Mating Anatomical Structure Development Neuron Development Retina Homeostasis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Mitochondrion Protein Complex Assembly Regulation Of Cellular Localization Immune System Process Platelet Degranulation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Synaptic Growth At Neuromuscular Junction Active Induction Of Host Immune Response By Virus Mitotic Sister Chromatid Segregation Protein Localization To Mitochondrion Protein Folding Cognition Neuron Projection Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Mitotic Nuclear Division Sister Chromatid Segregation Regulation Of Establishment Of Protein Localization	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Dedifferentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fas Signaling Pathway Cell Communication By Chemical Coupling Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Senescence Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome Organization Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Hematopoietic Stem Cell Differentiation Cell Communication By Electrical Coupling Negative Regulation Of Cell Aging Mitotic Sister Chromatid Cohesion Dentate Gyrus Development Type B Pancreatic Cell Development Negative Regulation Of Viral Transcription Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Astrocyte Development Type B Pancreatic Cell Differentiation Cell Cycle Lateral Ventricle Development Enteroendocrine Cell Differentiation Cell Division
Tagcloud ?			12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Difference) ?			12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Intersection) ?