PRSS23 and EFNA3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRSS23	EFNA3
Description		serine protease 23	ephrin A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Proteolysis	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Optic disc size ( 31809533) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432)
Interacting Genes		27 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4 UBC	11 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23
Entrez ID		11098	1944
HPRD ID		07149	03225
Ensembl ID		ENSG00000150687	ENSG00000143590
Uniprot IDs		O95084	P52797
PDB IDs
Enriched GO Terms of Interacting Partners?			Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Protein Tyrosine Kinase Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Regulation Of GTPase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Nephric Duct Morphogenesis Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Axonal Fasciculation Neuron Projection Fasciculation Ephrin Receptor Binding Dendrite Neuron Projection Development Growth Factor Binding Regulation Of Catalytic Activity Neuron Recognition Notochord Cell Development DH Domain Binding Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Plasma Membrane Tube Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Morphogenesis Of An Epithelium Axial Mesoderm Formation Neuromuscular Junction Positive Regulation Of Protein Localization To Membrane ATP Binding Regulation Of Cell Adhesion Keratin Filament Negative Regulation Of Lymphangiogenesis Notochord Formation Schaffer Collateral - CA1 Synapse Plasma Membrane Bounded Cell Projection Organization Postsynaptic Density Membrane Tissue Morphogenesis Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Blood Vessel Endothelial Cell Migration
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