Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
PRSS23 and SHMT1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PRSS23
SHMT1
Gene Name
protease, serine, 23
serine hydroxymethyltransferase 1 (soluble)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Extracellular Vesicular Exosome
Molecular Function
Serine-type Endopeptidase Activity
Glycine Hydroxymethyltransferase Activity
L-allo-threonine Aldolase Activity
Amino Acid Binding
Pyridoxal Phosphate Binding
Protein Homodimerization Activity
Biological Process
Proteolysis
L-serine Catabolic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Purine Nucleobase Biosynthetic Process
Glycine Biosynthetic Process From Serine
Cellular Nitrogen Compound Metabolic Process
Tetrahydrofolate Interconversion
Small Molecule Metabolic Process
Carnitine Biosynthetic Process
Folic Acid Metabolic Process
Protein Tetramerization
Protein Homotetramerization
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective GIF causes intrinsic factor deficiency
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Metabolism of amino acids and derivatives
Defective MMAA causes methylmalonic aciduria type cblA
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Carnitine synthesis
Metabolism of folate and pterines
Defective TCN2 causes hereditary megaloblastic anemia
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Drugs
Pyridoxal Phosphate
Tetrahydrofolic acid
Glycine
Mimosine
Triglu-5-Formyl-Tetrahydrofolate
5-Hydroxymethylene-6-Hydrofolic Acid
N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions
25 interactors:
ACTG1
APP
B2M
CHP1
EFNA3
FXR1
GRK6
HSPA4
MAPK8IP2
NCAPD3
NIPBL
NOC4L
ODF2L
PDDC1
PDPK1
PHF23
PPIA
RACGAP1
RECQL4
RPL4P5
SHMT1
SLC25A6
TCF12
TMEM222
TRAPPC4
7 interactors:
CSNK2B
DEDD
DLEU1
MAPK9
PIM1
PRSS23
SULT1A3
Entrez ID
11098
6470
HPRD ID
07149
01643
Ensembl ID
ENSG00000150687
ENSG00000176974
Uniprot IDs
B4E2J3
O95084
B4DPM9
P34896
PDB IDs
1BJ4
Enriched GO Terms of Interacting Partners
?
Platelet Activation
Blood Coagulation
Hemostasis
Cell Differentiation
Cellular Component Assembly
Regulation Of Body Fluid Levels
Organelle Organization
Wound Healing
Multicellular Organismal Development
Generation Of Neurons
Cell Activation
Dendrite Development
System Development
Response To Stress
Response To Wounding
Neurogenesis
Mating Behavior
Nervous System Development
Regulation Of Protein Localization
Response To Stimulus
Neuron Projection Development
Cell Development
Developmental Process
Cytokinesis, Initiation Of Separation
Actomyosin Contractile Ring Assembly
Uncoating Of Virus
Mating
Anatomical Structure Development
Neuron Development
Retina Homeostasis
Movement Of Cell Or Subcellular Component
Cell Morphogenesis Involved In Neuron Differentiation
Protein Targeting To Mitochondrion
Protein Complex Assembly
Regulation Of Cellular Localization
Immune System Process
Platelet Degranulation
Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Synaptic Growth At Neuromuscular Junction
Active Induction Of Host Immune Response By Virus
Mitotic Sister Chromatid Segregation
Protein Localization To Mitochondrion
Protein Folding
Cognition
Neuron Projection Morphogenesis
Positive Regulation Of Cellular Protein Metabolic Process
Neuron Differentiation
Mitotic Nuclear Division
Sister Chromatid Segregation
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
JUN Phosphorylation
Apoptotic Process
Regulation Of Catalytic Activity
Programmed Cell Death
Positive Regulation Of Prostaglandin Biosynthetic Process
Cell Death
Death
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Activin Receptor Signaling Pathway
Adiponectin-activated Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Endothelial Tube Morphogenesis
Protein Phosphorylation
Apoptotic Signaling Pathway
Protein Metabolic Process
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Prostaglandin Secretion
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Apoptotic Process
3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Positive Regulation Of Catalytic Activity
Regulation Of Transcription From RNA Polymerase I Promoter
Regulation Of Cell Death
Positive Regulation Of Icosanoid Secretion
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Metabolic Process
Sulfation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Positive Regulation Of Fatty Acid Transport
Flavonoid Metabolic Process
Decidualization
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud
?
aa
aas
african
american
ancestry
asian
associations
carbon
circle
comparisons
copyright
correcting
ea
eas
eleven
european
folate
metabolizing
modest
mtr
mtrr
participated
polygenetic
polymorphisms
reserved
rights
slc19a1
snps
tyms
Tagcloud (Difference)
?
aa
aas
african
american
ancestry
asian
associations
carbon
circle
comparisons
copyright
correcting
ea
eas
eleven
european
folate
metabolizing
modest
mtr
mtrr
participated
polygenetic
polymorphisms
reserved
rights
slc19a1
snps
tyms
Tagcloud (Intersection)
?