SLX1B and TUBA1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SLX1B	TUBA1B
Description		structure-specific endonuclease subunit SLX1B	tubulin alpha 1b
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Slx1-Slx4 Complex	Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton
	Molecular Function	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division Cellular Response To Interleukin-4
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin RHOH GTPase cycle HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS			Ambidextrousness ( 32989287) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes		3 interacting genes: DUSP10 THAP11 TUBA1B	39 interacting genes: A2M AGTRAP EML4 EPN2 ESR1 FOXP1 FYN GRM7 GZMM HDAC6 ISG15 LINC00624 MAPT MINK1 MTCL1 MYC NFKBIA OGT PFDN5 PIK3R1 PSEN1 PTEN PTP4A1 PTPRF PXN RNF26 RSPH1 RUNX1 SIAH1 SLX1B SMAD2 SNAP91 SRPK2 SUMO2 TERT TMEM253 TOM1L1 TUBG1 WEE2-AS1
Entrez ID		79008	10376
HPRD ID		14673	03960
Ensembl ID		ENSG00000181625	ENSG00000123416
Uniprot IDs		Q9BQ83	P68363
PDB IDs			2E4H 5IJ0 5IJ9 5N5N 6E7B 6E7C 6I2I 6J4V 6J8O 6QUS 6QUY 6QVE 6QVJ 6S8L 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 7ZCW 8T42 8U3Z 8V2J 8VA2 8VRJ 8VRK 8VT7 9BP6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelium Regeneration DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Pyrimidine Deoxyribonucleotide Binding Regulation Of Epithelium Regeneration Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Mitogen-activated Protein Kinase P38 Binding MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Nucleoside Triphosphate Diphosphatase Activity DNA Protection Protein Tyrosine/threonine Phosphatase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response JUN Kinase Binding Negative Regulation Of P38MAPK Cascade Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Mitochondrial Transcription Nucleoside Triphosphate Catabolic Process Pyrophosphatase Activity Hydrolase Activity Negative Regulation Of Oligodendrocyte Differentiation MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of Epithelial Cell Migration Pyrimidine Deoxyribonucleotide Catabolic Process Regulation Of Respiratory Burst Cellular Response To Interleukin-4 Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glial Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Pyrimidine-containing Compound Catabolic Process Response To Interleukin-4 Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process	Negative Regulation Of Developmental Process Beta-catenin Binding Neuron Projection Organization Negative Regulation Of Cellular Component Organization Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Signal Transduction Regulation Of Cell Development Regulation Of Cell Communication Regulation Of Signaling Response To Stress Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Protein Localization To Nucleus Enzyme Binding Negative Regulation Of Cell Development Positive Regulation Of Protein Oligomerization Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Growth Factor Receptor Binding Dendritic Spine Organization Ubiquitin Protein Ligase Binding Negative Regulation Of Myeloid Cell Differentiation Organelle Organization Clathrin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuron Projection Development Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Neuron Projection Regulation Of Cell Differentiation Cellular Response To Reactive Oxygen Species Cellular Response To Stress Alpha-tubulin Binding Tau Protein Binding Postsynapse Organization Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Protein Localization Negative Regulation Of Gene Expression Protein Modification Process Regulation Of Establishment Of Protein Localization Inclusion Body Assembly Regulation Of Myeloid Leukocyte Differentiation
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