SLX1B and DCTPP1

Data Source: HiPPIP (Novel)

		SLX1B	DCTPP1
Name		structure-specific endonuclease subunit SLX1B	dCTP pyrophosphatase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Slx1-Slx4 Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Interconversion of nucleotide di- and triphosphates
GWAS		No GWAS studies recorded	Urinary sodium excretion ( 31409800 )
Novel Interactors		1 novel interactors: DCTPP1	10 novel interactors: ARMC5 GDPD3 PAGR1 PRR14 RUSF1 SLX1B VKORC1 ZNF668 ZNF747 ZNF768
Interacting Genes		3 interacting genes: DUSP10 THAP11 TUBA1B	12 interacting genes: APP FMR1 FXR1 FXR2 LNX1 NIF3L1 NOA1 NTAQ1 PSMA1 SDCBP SPG21 USP7
Entrez ID		79008	79077
HPRD ID		14673	18310
Ensembl ID		ENSG00000181625	ENSG00000179958
Uniprot IDs		Q9BQ83	Q9H773
PDB IDs		Not available	7MU5
GO Terms Enriched among Interactors		Negative Regulation Of Epithelium Regeneration DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Pyrimidine Deoxyribonucleotide Binding Regulation Of Epithelium Regeneration Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Mitogen-activated Protein Kinase P38 Binding MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Nucleoside Triphosphate Diphosphatase Activity DNA Protection Protein Tyrosine/threonine Phosphatase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response JUN Kinase Binding Negative Regulation Of P38MAPK Cascade Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Mitochondrial Transcription Nucleoside Triphosphate Catabolic Process Pyrophosphatase Activity Hydrolase Activity Negative Regulation Of Oligodendrocyte Differentiation MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of Epithelial Cell Migration Pyrimidine Deoxyribonucleotide Catabolic Process Regulation Of Respiratory Burst Cellular Response To Interleukin-4 Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glial Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Pyrimidine-containing Compound Catabolic Process Response To Interleukin-4 Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity