SLX1B and DUSP10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SLX1B	DUSP10
Gene Name		SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	dual specificity phosphatase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Slx1-Slx4 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Response To Stress JNK Cascade Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Brown Fat Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440)
Protein-Protein Interactions		3 interactors: DUSP10 THAP11 TUBA1B	12 interactors: CMTM6 FHL2 FN1 HTT MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 RPS11 SLX1B SNX2
Entrez ID		79008	11221
HPRD ID		14673	12320
Ensembl ID		ENSG00000181625	ENSG00000143507
Uniprot IDs		Q9BQ83	B4DDQ0 Q9Y6W6
PDB IDs			1ZZW 2OUC 2OUD 3TG1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Brown Fat Cell Differentiation Regulation Of Respiratory Burst Negative Regulation Of JUN Kinase Activity	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of MAPK Activity Immune Response-regulating Signaling Pathway JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Defense Response Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cellular Response To Lipid Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Response To Radiation Response To Stress Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Kinase Activity
Tagcloud ?			bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Difference) ?			bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Intersection) ?