CHML and RAB5A

Number of citations of the paper that reports this interaction (PMID 8294464)
30

Data Source:
HPRD (in vitro)

		CHML	RAB5A
Gene Name		choroideremia-like (Rab escort protein 2)	RAB5A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity GTPase Activator Activity Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding
	Biological Process	Intracellular Protein Transport Protein Geranylgeranylation Positive Regulation Of GTPase Activity	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: RAB1A RAB3A RAB5A RAB6A RABGGTB	41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL
Entrez ID		1122	5868
HPRD ID		00341	01542
Ensembl ID		ENSG00000203668	ENSG00000144566
Uniprot IDs		P26374	B4DJA5 P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Intracellular Protein Transport Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling Establishment Of Organelle Localization Regulation Of Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Neuronal Synaptic Plasticity Organelle Transport Along Microtubule Organelle Localization Protein Transport Positive Regulation Of Exocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Transport Intracellular Signal Transduction Endocytosis Protein Localization Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Cytoplasmic Transport Establishment Of Localization In Cell Protein Secretion Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Regulation Of Exocytosis Regulation Of Synaptic Plasticity Cellular Localization Cell-cell Signaling Peptidyl-cysteine Methylation Constitutive Secretory Pathway Regulation Of Endosome Size Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Sensory Perception Of Touch Receptor Internalization Involved In Canonical Wnt Signaling Pathway Minus-end-directed Organelle Transport Along Microtubule Endosomal Transport Vesicle Organization Interleukin-8 Production Golgi Vesicle Transport Protein Geranylgeranylation Regulation Of Synaptic Transmission Microtubule-based Movement	Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion
Tagcloud ?			accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Difference) ?			accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Intersection) ?