RAB1B and MICAL1

Number of citations of the paper that reports this interaction (PubMedID 15796781)
57

Data Source:
HPRD (two hybrid)

		RAB1B	MICAL1
Description		RAB1B, member RAS oncogene family	microtubule associated monooxygenase, calponin and LIM domain containing 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phagophore Assembly Site Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Intermediate Filament Actin Filament Plasma Membrane Cilium Endosome Membrane Actin Cytoskeleton Membrane Midbody Ciliary Basal Body Intercellular Bridge Plasma Membrane Bounded Cell Projection Hippocampal Mossy Fiber Expansion
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity	Actin Binding Monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding F-actin Monooxygenase Activity
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Golgi Organization Protein Transport Virion Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Autophagosome Assembly	Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Depression in smokers ( 30219690) Height ( 28552196)
Interacting Genes		12 interacting genes: APP CHM FNDC3B GDI1 GOLGA2 LINC00632 MICAL1 MICAL3 RABIF RUSC2 SMARCC2 TOMM40L	16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		81876	64780
HPRD ID		11469	06183
Ensembl ID		ENSG00000174903	ENSG00000135596
Uniprot IDs		Q9H0U4	Q8TDZ2
PDB IDs		3JZA 3NKV 4HLQ 4I1O 5O74 5SZH 5SZK 6SKU 8ALK	1WYL 2CO8 2DK9 5LE0 5LPN 6KU0 8HLO 8Y6K 9EWY
Enriched GO Terms of Interacting Partners?		F-actin Monooxygenase Activity Small GTPase Binding Actin Filament Depolymerization Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Protein-containing Complex Disassembly Regulation Of Toll-like Receptor Signaling Pathway Midbody FAD Binding Protein Depolymerization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Transport Small GTPase-mediated Signal Transduction Actin Polymerization Or Depolymerization Golgi Vesicle Transport Monooxygenase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Protein Localization Rab GDP-dissociation Inhibitor Activity Sulfur Oxidation Hippocampal Mossy Fiber Expansion Protein-containing Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Intercellular Bridge Intracellular Signaling Cassette Post-Golgi Vesicle-mediated Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion SH2 Domain Binding Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Organelle Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Cell Migration Scaffold Protein Binding Positive Regulation Of Cell Motility Negative Regulation Of Anoikis ERBB Signaling Pathway Positive Regulation Of Locomotion Nucleotide Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Establishment Of Cell Polarity Regulation Of Cell Projection Organization Protein Domain Specific Binding Regulation Of Anoikis Integrin-mediated Signaling Pathway Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cellular Response To Fluid Shear Stress Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Epithelial Cell Development Regulation Of Cytoskeleton Organization Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Metabolic Process Developmental Process Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Mononuclear Cell Migration
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