FAM107A and MTREX

Number of citations of the paper that reports this interaction (PubMedID 28604741)
0

Data Source:
BioGRID (two hybrid)

		FAM107A	MTREX
Description		family with sequence similarity 107 member A	Mtr4 exosome RNA helicase
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Nuclear Speck Ruffle Membrane Cell Projection Neuron Projection Synapse Anchoring Junction	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Regulation Of Cell Growth Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing MRNA Processing RNA Catabolic Process DNA Damage Response RNA Splicing SnRNA Catabolic Process
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47	17 interacting genes: CEBPA DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 USP7 XRN1
Entrez ID		11170	23517
HPRD ID		09753	13777
Ensembl ID		ENSG00000168309	ENSG00000039123
Uniprot IDs		O95990 Q6IAM1	P42285 Q3MHC9
PDB IDs			6C90 6D6Q 6D6R 6IEG 6IEH 6RO1 7S7B 7S7C 7Z4Y 7Z4Z 7Z52
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Microtubule Structural Constituent Of Skin Epidermis Meiosis I Cell Cycle Process Female Meiosis I Supramolecular Fiber Organization	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process SnRNA 3'-end Processing RNA Catabolic Process SnRNA Processing Exoribonuclease Complex RRNA Metabolic Process SnRNA Metabolic Process RRNA Processing Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Gene Expression Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Nucleolus Macromolecule Catabolic Process MRNA 3'-UTR AU-rich Region Binding RNA Binding Nucleobase-containing Compound Metabolic Process RNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA Deamination Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA Modification
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