FAM107A and AUH

Number of citations of the paper that reports this interaction (PubMedID 28604741)
0

Data Source:
BioGRID (two hybrid)

		FAM107A	AUH
Description		family with sequence similarity 107 member A	AU RNA binding methylglutaconyl-CoA hydratase
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Nuclear Speck Ruffle Membrane Cell Projection Neuron Projection Synapse Anchoring Junction	Mitochondrion Mitochondrial Matrix
	Molecular Function	Actin Binding Protein Binding	RNA Binding MRNA 3'-UTR Binding Catalytic Activity Enoyl-CoA Hydratase Activity Methylglutaconyl-CoA Hydratase Activity Lyase Activity Itaconyl-CoA Hydratase Activity
	Biological Process	Regulation Of Cell Growth Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	L-leucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process
Pathways			Branched-chain amino acid catabolism 3-methylglutaconic aciduria
Drugs
Diseases			3-Methylglutaconic aciduria (MGCA)
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Response to Homoharringtonine (cytotoxicity) ( 25628645) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total bilirubin levels ( 29403010) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47	1 interacting genes: FAM107A
Entrez ID		11170	549
HPRD ID		09753	08987
Ensembl ID		ENSG00000168309	ENSG00000148090
Uniprot IDs		O95990 Q6IAM1	B4DYI6 Q13825
PDB IDs			1HZD 2ZQQ 2ZQR
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Microtubule Structural Constituent Of Skin Epidermis Meiosis I Cell Cycle Process Female Meiosis I Supramolecular Fiber Organization	Regulation Of Long-term Synaptic Potentiation Regulation Of Cell-substrate Junction Organization Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Actin Polymerization Or Depolymerization Actin Filament Polymerization Regulation Of Focal Adhesion Assembly Actin Filament Bundle Organization Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Polymerization Negative Regulation Of Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cell-substrate Adhesion Cellular Response To Steroid Hormone Stimulus Stress Fiber Ruffle Membrane Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Corticosteroid Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Synaptic Plasticity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Response To Steroid Hormone Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Cycle Phase Transition Regulation Of Microtubule-based Process Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Actin Cytoskeleton Negative Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cognition Neuron Projection Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Hormone Stimulus Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Actin Filament-based Process
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