FAM107A and CPSF3

Number of citations of the paper that reports this interaction (PubMedID 28604741)
0

Data Source:
BioGRID (two hybrid)

		FAM107A	CPSF3
Description		family with sequence similarity 107 member A	cleavage and polyadenylation specific factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Nuclear Speck Ruffle Membrane Cell Projection Neuron Projection Synapse Anchoring Junction	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex
	Molecular Function	Actin Binding Protein Binding	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47	10 interacting genes: CLP1 FAM107A HSPB1 MIR19A MIR19B1 MIR92A2 PAPOLA POLR2A RBBP6 YWHAG
Entrez ID		11170	51692
HPRD ID		09753	05825
Ensembl ID		ENSG00000168309	ENSG00000119203
Uniprot IDs		O95990 Q6IAM1	G5E9W3 Q9UKF6
PDB IDs			2I7T 2I7V 6M8Q 6V4X 8T1Q 8T1R
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Microtubule Structural Constituent Of Skin Epidermis Meiosis I Cell Cycle Process Female Meiosis I Supramolecular Fiber Organization	Post-transcriptional Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly RISC Complex Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Inflammatory Response To Antigenic Stimulus MRNA 3'-end Processing Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Immune Response Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Fibroblast Migration MRNA Metabolic Process Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Protein Kinase C Binding Positive Regulation Of Organ Growth Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Protein Secretion Positive Regulation Of Muscle Cell Differentiation
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