FAM107A and HFM1

Number of citations of the paper that reports this interaction (PubMedID 28604741)
0

Data Source:
BioGRID (two hybrid)

		FAM107A	HFM1
Description		family with sequence similarity 107 member A	helicase for meiosis 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Nuclear Speck Ruffle Membrane Cell Projection Neuron Projection Synapse Anchoring Junction	Nucleus
	Molecular Function	Actin Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Helicase Activity Helicase Activity ATP Binding Zinc Ion Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Resolution Of Meiotic Recombination Intermediates Reciprocal Meiotic Recombination Meiotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)	Metabolite levels ( 23823483) Response to fenofibrate (HDL cholesterol levels) ( 27002377)
Interacting Genes		58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47	2 interacting genes: FAM107A RPS27L
Entrez ID		11170	164045
HPRD ID		09753	18568
Ensembl ID		ENSG00000168309	ENSG00000162669
Uniprot IDs		O95990 Q6IAM1	A2PYH4 B4DYS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Microtubule Structural Constituent Of Skin Epidermis Meiosis I Cell Cycle Process Female Meiosis I Supramolecular Fiber Organization	Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Long-term Synaptic Potentiation Translation Activator Activity Ribosomal Small Subunit Assembly Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Focal Adhesion Assembly Actin Filament Polymerization Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Cell-matrix Adhesion Cytosolic Small Ribosomal Subunit Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Actin Polymerization Or Depolymerization Regulation Of Focal Adhesion Assembly Actin Filament Bundle Organization Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Protein-containing Complex Organization Actin Filament Bundle Assembly Negative Regulation Of Cell-substrate Adhesion Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell-substrate Junction Organization Protein Polymerization Mitotic DNA Integrity Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Steroid Hormone Stimulus Stress Fiber Ruffle Membrane DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification
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