PTP4A3 and FNTA

Number of citations of the paper that reports this interaction (PubMedID 10747914)
0

Data Source:
HPRD (in vitro)

		PTP4A3	FNTA
Description		protein tyrosine phosphatase 4A3	farnesyltransferase, CAAX box, subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Plasma Membrane Membrane	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Receptor Tyrosine Kinase Binding Alpha-tubulin Binding Molecular Adaptor Activity
	Biological Process	Regulation Of DNA-templated Transcription Notch Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Vascular Permeability Endothelial Cell Migration Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Establishment Of Protein Localization Cellular Response To Leukemia Inhibitory Factor	Nuclear Envelope Organization Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Pheromone Maturation Neuromuscular Junction Development Protein Farnesylation Protein Geranylgeranylation Positive Regulation Of Rac Protein Signal Transduction Protein Maturation Regulation Of Microtubule-based Movement Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways			Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs			AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Diastolic blood pressure ( 27841878) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 27841878)	Zinc levels ( 26025379)
Interacting Genes		4 interacting genes: CDKN2A FNTA FNTB FZR1	22 interacting genes: ACVR1 AP4M1 CENPF CFTR FNTB GBP1 GRSF1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2
Entrez ID		11156	2339
HPRD ID		05922	00607
Ensembl ID		ENSG00000184489	ENSG00000168522
Uniprot IDs		O75365	P49354
PDB IDs		1R6H 1V3A 2MBC 5TSR	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Protein Prenyltransferase Activity Protein Prenylation Protein Localization To Nucleolus Prenyltransferase Activity Acetyltransferase Activator Activity Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Post-translational Protein Modification Microtubule Associated Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Microtubule-based Movement Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Localization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Protein Ubiquitination Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Regulation Of Mitotic Cell Cycle Peptide Pheromone Maturation DNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Protein Modification Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Post-translational Protein Modification CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Cell Cycle Process Positive Regulation Of Macrophage Apoptotic Process Regulation Of Protein Localization To Nucleus Apoptotic Process Involved In Mammary Gland Involution DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Localization To Nucleus Senescence-associated Heterochromatin Focus Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Protein Neddylation	Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Tissue Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction GDP Binding Morphogenesis Of An Epithelium Response To Cholesterol Protein Localization To Vacuole Activin Receptor Signaling Pathway Regulation Of Protein Localization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Protein Prenyltransferase Activity Response To Alcohol Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Non-canonical Inflammasome Complex Assembly Myofibroblast Differentiation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tube Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Enamel Mineralization Positive Regulation Of Mesenchymal Stem Cell Proliferation Developmental Process Morphogenesis Of A Branching Epithelium Regulation Of Establishment Of Protein Localization Response To Lipid Regulation Of Protein Localization To Cell Periphery Regulation Of Programmed Cell Death Germ Cell Migration Morphogenesis Of A Branching Structure Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Migration Protein Prenylation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Prenyltransferase Activity Regulation Of Protein Localization To Membrane
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