PTP4A3

Description		protein tyrosine phosphatase 4A3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of DNA-templated Transcription Notch Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Vascular Permeability Endothelial Cell Migration Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Establishment Of Protein Localization Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 27841878)
Novel Interacting Genes		1 novel interacting genes: PINX1
Interacting Genes		4 interacting genes: CDKN2A FNTA FNTB FZR1
Entrez ID		11156
HPRD ID		05922
Ensembl ID		ENSG00000184489
Uniprot IDs		O75365
PDB IDs		1R6H 1V3A 2MBC 5TSR
Enriched GO Terms of Interacting Partners?		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Protein Prenyltransferase Activity Protein Prenylation Protein Localization To Nucleolus Prenyltransferase Activity Acetyltransferase Activator Activity Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Post-translational Protein Modification Microtubule Associated Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Microtubule-based Movement Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Localization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Protein Ubiquitination Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Regulation Of Mitotic Cell Cycle Peptide Pheromone Maturation DNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Protein Modification Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Post-translational Protein Modification CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Cell Cycle Process Positive Regulation Of Macrophage Apoptotic Process Regulation Of Protein Localization To Nucleus Apoptotic Process Involved In Mammary Gland Involution DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Localization To Nucleus Senescence-associated Heterochromatin Focus Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Protein Neddylation
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