CORO1A and NCF4

Number of citations of the paper that reports this interaction (PubMedID 9365277)
0

Data Source:
HPRD (in vitro)

		CORO1A	NCF4
Description		coronin 1A	neutrophil cytosolic factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Phagocytic Cup Nucleus Cytoplasm Early Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Cell Cortex Actin Cytoskeleton Membrane Lamellipodium Axon Phagocytic Vesicle Membrane Cortical Actin Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Synapse Phagocytic Vesicle Extracellular Exosome Glutamatergic Synapse	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	RNA Binding Actin Binding Actin Monomer Binding Protein Binding Cytoskeletal Protein Binding Myosin Heavy Chain Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding Actin Filament Binding	Protein Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Immunological Synapse Formation Phagolysosome Assembly Calcium Ion Transport Vesicle Fusion Phagocytosis Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Epithelial Cell Migration Cell Migration Actin Cytoskeleton Organization Leukocyte Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of Vesicle Fusion Cell-substrate Adhesion Uropod Organization Regulation Of Actin Cytoskeleton Organization Response To Cytokine Nerve Growth Factor Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation T Cell Homeostasis Natural Killer Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of T Cell Activation Positive Chemotaxis Negative Regulation Of Actin Nucleation Negative Regulation Of Cellular Component Organization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Early Endosome To Recycling Endosome Transport Cellular Response To Interleukin-4 T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration	Phagocytosis Superoxide Anion Generation Respiratory Burst
Pathways		Prevention of phagosomal-lysosomal fusion	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hodgkin's lymphoma ( 30194254) Tonsillectomy ( 27182965 28928442)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		21 interacting genes: ACTB CEBPA FHL3 FSD2 FXR1 GIT2 GOLGA2 IFT20 LMO2 MAGEA11 MAGOH NCF4 POLR1C POT1 SMAD3 SMARCD1 SPATA20 STAT3 TAB1 THBS1 YTHDC1	11 interacting genes: CORO1A CRYAA CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		11151	4689
HPRD ID		05414	03289
Ensembl ID		ENSG00000102879	ENSG00000100365
Uniprot IDs		P31146	A0A494BZS1 Q15080
PDB IDs			1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex GBAF Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase I Chromatin DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Factor Binding Osteoblast Development DEAD/H-box RNA Helicase Binding Nuclear Glucocorticoid Receptor Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Nucleoplasm Nuclear Matrix SWI/SNF Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process BHLH Transcription Factor Binding Positive Regulation Of Extracellular Matrix Organization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process MRNA Transport RNA Transport Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Positive Regulation Of Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Multicellular Organismal Development Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B	Superoxide-generating NAD(P)H Oxidase Activity NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide Metabolic Process Innate Immune Response Hydrogen Peroxide Biosynthetic Process Response To Other Organism Electron Transfer Activity Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Radiation Reactive Oxygen Species Biosynthetic Process Response To External Biotic Stimulus Defense Response Response To Angiotensin Cellular Response To L-glutamine Phagolysosome DNA-dependent Protein Kinase Complex Response To Gamma Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Response To Stress Nonhomologous End Joining Complex Regulation Of Immune System Process Superoxide-generating NADPH Oxidase Activator Activity Phagocytic Vesicle Membrane Regulation Of Intracellular Transport Response To Peptide Hormone Immunological Synapse Formation Cellular Response To Angiotensin Lymphocyte Proliferation Response To Aldosterone Cytoplasm Mononuclear Cell Proliferation Perinuclear Endoplasmic Reticulum Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Leukocyte Proliferation Peptidyl-threonine Phosphorylation Response To Ionizing Radiation Regulation Of Defense Response Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Oxygen-containing Compound Regulation Of Innate Immune Response Cellular Response To Gamma Radiation Lymphocyte Activation
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