CORO1A and SPATA20

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CORO1A	SPATA20
Description		coronin 1A	spermatogenesis associated 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Phagocytic Cup Nucleus Cytoplasm Early Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Cell Cortex Actin Cytoskeleton Membrane Lamellipodium Axon Phagocytic Vesicle Membrane Cortical Actin Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Synapse Phagocytic Vesicle Extracellular Exosome Glutamatergic Synapse	Extracellular Region Mitochondrion
	Molecular Function	RNA Binding Actin Binding Actin Monomer Binding Protein Binding Cytoskeletal Protein Binding Myosin Heavy Chain Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding Actin Filament Binding
	Biological Process	Immunological Synapse Formation Phagolysosome Assembly Calcium Ion Transport Vesicle Fusion Phagocytosis Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Epithelial Cell Migration Cell Migration Actin Cytoskeleton Organization Leukocyte Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of Vesicle Fusion Cell-substrate Adhesion Uropod Organization Regulation Of Actin Cytoskeleton Organization Response To Cytokine Nerve Growth Factor Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation T Cell Homeostasis Natural Killer Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of T Cell Activation Positive Chemotaxis Negative Regulation Of Actin Nucleation Negative Regulation Of Cellular Component Organization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Early Endosome To Recycling Endosome Transport Cellular Response To Interleukin-4 T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration	Carbohydrate Metabolic Process Spermatogenesis Cell Differentiation
Pathways		Prevention of phagosomal-lysosomal fusion
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hodgkin's lymphoma ( 30194254) Tonsillectomy ( 27182965 28928442)	Blood protein levels ( 30072576) Hip index ( 34021172) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		21 interacting genes: ACTB CEBPA FHL3 FSD2 FXR1 GIT2 GOLGA2 IFT20 LMO2 MAGEA11 MAGOH NCF4 POLR1C POT1 SMAD3 SMARCD1 SPATA20 STAT3 TAB1 THBS1 YTHDC1	3 interacting genes: CORO1A ST6GALNAC4 XRN1
Entrez ID		11151	64847
HPRD ID		05414	07961
Ensembl ID		ENSG00000102879	ENSG00000006282
Uniprot IDs		P31146	Q8TB22
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex GBAF Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase I Chromatin DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Factor Binding Osteoblast Development DEAD/H-box RNA Helicase Binding Nuclear Glucocorticoid Receptor Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Nucleoplasm Nuclear Matrix SWI/SNF Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process BHLH Transcription Factor Binding Positive Regulation Of Extracellular Matrix Organization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process MRNA Transport RNA Transport Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Positive Regulation Of Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Multicellular Organismal Development Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B	Cellular Response To Puromycin Cellular Response To Cycloheximide Uropod Organization Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase Activity Phagolysosome Assembly Negative Regulation Of Vesicle Fusion Thymocyte Migration Early Endosome To Recycling Endosome Transport Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Response To Cycloheximide 5'-3' RNA Exonuclease Activity Natural Killer Cell Degranulation Myosin Heavy Chain Binding Negative Regulation Of Actin Nucleation G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Ganglioside Biosynthetic Process Immunological Synapse Formation Nerve Growth Factor Signaling Pathway Histone MRNA Catabolic Process Phosphatidylinositol 3-kinase Binding Sialyltransferase Activity RRNA Catabolic Process Neurotrophin Signaling Pathway Negative Regulation Of Cellular Component Organization Positive Regulation Of T Cell Migration Regulation Of Vesicle Fusion T Cell Homeostasis Response To Interleukin-4 Phagocytic Cup Actin Monomer Binding T Cell Migration Epithelial Cell Migration Cellular Response To Interleukin-4 Regulation Of Actin Nucleation Glycosphingolipid Biosynthetic Process Ganglioside Metabolic Process Viral Protein Processing Protein O-linked Glycosylation Via N-acetyl-galactosamine Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear RNA Surveillance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Histone MRNA Metabolic Process Leukocyte Degranulation Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Telomere Maintenance
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