CHGA and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CHGA	PFDN1
Description		chromogranin A	prefoldin subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transport Vesicle Secretory Granule Cytoplasmic Vesicle Chromaffin Granule Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function		Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Mast Cell Chemotaxis Regulation Of Blood Pressure Killing Of Cells Of Another Organism Protein Localization To Secretory Granule Negative Regulation Of Catecholamine Secretion Defense Response To Bacterium Mast Cell Degranulation Innate Immune Response Mast Cell Activation Negative Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Dense Core Granule Biogenesis	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Antimicrobial peptides	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Body mass index ( 26426971)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		6 interacting genes: CDC37 NEK2 PFDN1 PLG SCG3 UBC	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		1113	5201
HPRD ID		07170	05357
Ensembl ID		ENSG00000100604	ENSG00000113068
Uniprot IDs		G5E968 P10645 Q86T07	O60925
PDB IDs		1LV4 6R2X	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Unfolded Protein Binding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein-folding Chaperone Binding Kinase Binding HSP90-CDC37 Chaperone Complex Protein Localization To Secretory Granule Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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