CHGA and SCG3

Number of citations: 41 (PubMedID 12388744)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		CHGA	SCG3
Name		chromogranin A	secretogranin III
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transport Vesicle Secretory Granule Cytoplasmic Vesicle Chromaffin Granule Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle	Extracellular Region Endoplasmic Reticulum Lumen Membrane Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Secretory Granule Lumen
	Molecular Function	None	RNA Binding Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Mast Cell Chemotaxis Regulation Of Blood Pressure Killing Of Cells Of Another Organism Protein Localization To Secretory Granule Negative Regulation Of Catecholamine Secretion Defense Response To Bacterium Mast Cell Degranulation Innate Immune Response Mast Cell Activation Negative Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Dense Core Granule Biogenesis	Protein Localization To Secretory Granule
Pathways		Antimicrobial peptides	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
GWAS		Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 )	Asthma ( 20159242 ) Blood protein levels ( 30072576 ) Intelligence (MTAG) ( 29326435 ) Mean reticulocyte volume ( 32888494 )
Interacting Genes		6 interacting genes: CDC37 NEK2 PFDN1 PLG SCG3 UBC	5 interacting genes: CHGA DNM1L NCAM2 NRIP1 SDCBP
Entrez ID		1113	29106
HPRD ID		07170	11538
Ensembl ID		ENSG00000100604	ENSG00000104112
Uniprot IDs		G5E968 P10645 Q86T07	Q8WXD2
PDB IDs		1LV4 6R2X	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Unfolded Protein Binding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein-folding Chaperone Binding Kinase Binding HSP90-CDC37 Chaperone Complex Protein Localization To Secretory Granule Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis	Positive Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Dense Core Granule Biogenesis Mast Cell Chemotaxis Regulation Of Secretion Chromaffin Granule Regulation Of Secretion By Cell Protein Localization To Secretory Granule Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Ovarian Follicle Rupture Mitochondrion-derived Vesicle Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Mitocytosis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Relaxation Of Cardiac Muscle Mast Cell Migration Regulation Of Extracellular Exosome Assembly Response To Gonadotropin-releasing Hormone Intracellular Distribution Of Mitochondria