CHGA and NEK2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CHGA	NEK2
Gene Name		chromogranin A (parathyroid secretory protein 1)	NIMA-related kinase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Secretory Granule Transport Vesicle Membrane Perinuclear Region Of Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein Complex Intercellular Bridge
	Molecular Function		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding
	Biological Process	Regulation Of Blood Pressure	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Organelle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways			Organelle biogenesis and maintenance APC/C:Cdc20 mediated degradation of mitotic proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CDC37 NEK2 PFDN1 PLG SCG3 UBC	23 interactors: CCDC85A CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 SPTBN4 TCF25 TPM3
Entrez ID		1113	4751
HPRD ID		07170	04953
Ensembl ID		ENSG00000100604	ENSG00000117650
Uniprot IDs		G5E968 P10645 Q86T07	P51955
PDB IDs		1LV4	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Centriole-centriole Cohesion Cellular Protein Catabolic Process Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Cell Activation Establishment Of Localization In Cell Mononuclear Cell Migration Regulation Of Centriole-centriole Cohesion Cellular Macromolecule Catabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Platelet Activation Cellular Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Mitotic Centrosome Separation Cellular Localization Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Folding Negative Regulation Of Fibrinolysis Viral Protein Processing Exocytosis Cell Cycle Protein Metabolic Process Regulation Of Fibrinolysis Centrosome Separation Regulation Of Mitotic Cell Cycle Blood Coagulation Proteolysis Hemostasis Mitotic Spindle Assembly Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Notch Receptor Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Virion Assembly Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Secretion By Cell In Utero Embryonic Development Modification-dependent Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Cell Cycle Regulation Of Centriole-centriole Cohesion Glycogen Metabolic Process Mitotic Cell Cycle Polysaccharide Metabolic Process Regulation Of Organelle Organization Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Movement Of Cell Or Subcellular Component Cell Cycle Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Energy Reserve Metabolic Process Mitotic Cell Cycle Process Microtubule-based Process Cell Division Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA-directed RNA Polymerase Activity Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Cellular Protein Localization Cellular Carbohydrate Metabolic Process Centrosome Cycle Cellular Response To Growth Factor Stimulus MAPK Import Into Nucleus Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chromosome Segregation Regulation Of Signal Transduction Cell Morphogenesis Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Response To Abiotic Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Mitotic Nuclear Division Neuron Differentiation Establishment Of Organelle Localization
Tagcloud ?		antibodies antigenic autoantibodies bdc2 cd4 chromogranin employed epitope extension flanking fragments g7 humoral immuno immunostaining islet kcvlevisd molecule nod overlap pancreatic peptide peptides register sections sequence sera titers truncation	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Difference) ?		antibodies antigenic autoantibodies bdc2 cd4 chromogranin employed epitope extension flanking fragments g7 humoral immuno immunostaining islet kcvlevisd molecule nod overlap pancreatic peptide peptides register sections sequence sera titers truncation	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Intersection) ?