BTN2A1 and CLDN19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTN2A1	CLDN19
Description		butyrophilin subfamily 2 member A1	claudin 19
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon
	Molecular Function	Signaling Receptor Binding Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity
	Biological Process	Regulation Of Cytokine Production Lipid Metabolic Process T Cell Receptor Signaling Pathway	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport
Pathways		Butyrophilin (BTN) family interactions	Tight junction interactions
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 33909500) Cutaneous mastocytosis ( 32752121) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586 34187846) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Lung cancer ( 31577861) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CLDN19 CTXN3 MAL NSG1 PLPP6 STRIT1	63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14
Entrez ID		11120	149461
HPRD ID		12544	10834
Ensembl ID		ENSG00000112763	ENSG00000164007
Uniprot IDs		Q7KYR7	Q8N6F1
PDB IDs		8DFW 8DFX 8DFY 8JYC 8JYE 8VC7
Enriched GO Terms of Interacting Partners?		Schmidt-Lanterman Incisure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Spontaneous Synaptic Transmission Mesaxon Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Membrane Raft Polarization Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Protein Localization To Paranode Region Of Axon Regulation Of Transepithelial Transport Establishment Of Protein Localization To Membrane Peptidase Activator Activity Involved In Apoptotic Process Postsynaptic Endosome Paracellular Tight Junction Channel Activity Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Membrane Raft Distribution Clathrin Light Chain Binding Paracellular Transport Lysophosphatidic Acid Phosphatase Activity Membrane Raft Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Apical Junction Assembly Retinal Pigment Epithelium Development Paranodal Junction Protein Prenylation Protein Localization To Axon Structural Constituent Of Myelin Sheath Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Neutrophil Activation Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Positive Regulation Of Receptor Recycling Endosome To Plasma Membrane Protein Transport	Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane
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