ENPP7 and LRRC73

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ENPP7	LRRC73
Description		ectonucleotide pyrophosphatase/phosphodiesterase 7	leucine rich repeat containing 73
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Microvillus Membrane
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Sphingomyelin Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Lipid Digestion Positive Regulation Of Intestinal Cholesterol Absorption Glycosphingolipid Catabolic Process Fatty Acid Homeostasis Regulation Of Intestinal Lipid Absorption Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Sphingomyelin Catabolic Process
Pathways		Glycosphingolipid catabolism
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: BACH2 GOLGA2 KRTAP5-9 LRRC73 MTUS2	9 interacting genes: CTDSP1 ENPP7 GADD45GIP1 LNX1 NTAQ1 PICK1 RPP25 SHANK3 TSHZ3
Entrez ID		339221	221424
HPRD ID		10938	10167
Ensembl ID		ENSG00000182156	ENSG00000204052
Uniprot IDs		Q6UWV6	Q3B825 Q5JTD7
PDB IDs		5TCD 5UDY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hippo Signaling	Regulation Of Synaptic Plasticity Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Positive Regulation Of Synaptic Transmission, Glutamatergic Receptor Clustering Protein-N-terminal Glutamine Amidohydrolase Activity Positive Regulation Of Intestinal Cholesterol Absorption Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Synaptic Transmission, Glutamatergic Guanylate Kinase-associated Protein Clustering Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Positive Regulation Of Phospholipid Catabolic Process Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Supramolecular Fiber Organization Membrane Curvature Sensor Activity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Cell Volume Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Sperm Flagellum Cilium Movement Involved In Cell Motility Axonemal Central Apparatus Assembly Radial Spoke Head Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Intestinal Cholesterol Absorption Regulation Of Phospholipid Catabolic Process Lipid Digestion Sphingomyelin Phosphodiesterase Activity Negative Regulation Of Actin Nucleation Regulation Of System Process Vocal Learning Neuron Spine Kinocilium Cilium Movement Ribonuclease MRP Complex Positive Regulation Of Long-term Neuronal Synaptic Plasticity Observational Learning
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