PRDM4 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDM4	NCS1
Description		PR/SET domain 4	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Nucleus Histone Methyltransferase Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport
Pathways		p75NTR negatively regulates cell cycle via SC1
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Acne (severe) ( 24927181) Daytime nap ( 33568662) Sleep duration ( 30846698)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		11 interacting genes: CFTR CTNNBL1 DYRK1A EIF4E EMX1 MSRB3 NCS1 RCAN1 RUNX1 SERTAD1 SMAD3	26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		11108	23413
HPRD ID		10425	04500
Ensembl ID		ENSG00000110851	ENSG00000107130
Uniprot IDs		B3KPI0 Q9UKN5	P62166
PDB IDs		2L9Z 3DB5	1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extracellular Matrix Organization Transcription Coactivator Binding DNA-binding Transcription Factor Binding Transcription Corepressor Binding Enzyme Binding Response To Stress Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Histone H3T45 Kinase Activity Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Somatic Diversification Of Immunoglobulins	Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?