PRDM4 and MSRB3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PRDM4	MSRB3
Description		PR/SET domain 4	methionine sulfoxide reductase B3
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GO Annotations	Cellular Component	Nucleus Histone Methyltransferase Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II	Response To Oxidative Stress Protein Repair
Pathways		p75NTR negatively regulates cell cycle via SC1	Protein repair
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Daytime nap ( 33568662) Sleep duration ( 30846698)	A body shape index ( 34021172) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		11 interacting genes: CFTR CTNNBL1 DYRK1A EIF4E EMX1 MSRB3 NCS1 RCAN1 RUNX1 SERTAD1 SMAD3	31 interacting genes: ASB13 BANP EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL SKIC8 TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 ZMYND12
Entrez ID		11108	253827
HPRD ID		10425	14785
Ensembl ID		ENSG00000110851	ENSG00000174099
Uniprot IDs		B3KPI0 Q9UKN5	Q8IXL7
PDB IDs		2L9Z 3DB5	6QA0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extracellular Matrix Organization Transcription Coactivator Binding DNA-binding Transcription Factor Binding Transcription Corepressor Binding Enzyme Binding Response To Stress Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Histone H3T45 Kinase Activity Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Somatic Diversification Of Immunoglobulins	Intermediate Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Methyltransferase Activity Protein Modification Process Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Methylation
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