PRDM4 and EMX1

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		PRDM4	EMX1
Name		PR/SET domain 4	empty spiracles homeobox 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Histone Methyltransferase Complex	Chromatin Nucleus Chromosome Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II	In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Post-embryonic Development Telencephalon Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension
Pathways		p75NTR negatively regulates cell cycle via SC1	None
GWAS		Acne (severe) ( 24927181 ) Daytime nap ( 33568662 ) Sleep duration ( 30846698 )	Malaria ( 31844061 ) Schizophrenia ( 28991256 30285260 )
Novel Interactors		2 novel interactors: DAO UNG	None recorded
Interacting Genes		11 interacting genes: CFTR CTNNBL1 DYRK1A EIF4E EMX1 MSRB3 NCS1 RCAN1 RUNX1 SERTAD1 SMAD3	8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63
Entrez ID		11108	2016
HPRD ID		10425	08963
Ensembl ID		ENSG00000110851	ENSG00000135638
Uniprot IDs		B3KPI0 Q9UKN5	Q04741
PDB IDs		2L9Z 3DB5	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Extracellular Matrix Organization Transcription Coactivator Binding DNA-binding Transcription Factor Binding Transcription Corepressor Binding Enzyme Binding Response To Stress Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Histone H3T45 Kinase Activity Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Somatic Diversification Of Immunoglobulins	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Limb Morphogenesis Transcription By RNA Polymerase II Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prostate Gland Development DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Skeletal System Development Proximal/distal Pattern Formation Embryonic Hindlimb Morphogenesis Sequence-specific Double-stranded DNA Binding Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Hindlimb Morphogenesis Forelimb Morphogenesis Response To Testosterone Hair Follicle Development Gland Development Macromolecule Biosynthetic Process Regionalization Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Ectoderm And Mesoderm Interaction Epidermal Cell Division DNA-templated Transcription Initiation Hair Cycle Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Chromatin RNA Polymerase Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Sequence-specific DNA Binding Neuron Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Female Genitalia Morphogenesis