IL24 and CCR5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL24	CCR5
Gene Name		interleukin 24	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Cytokine Activity	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Apoptotic Process Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Migration Serine Phosphorylation Of STAT3 Protein Wound Healing Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Celiac disease ( 20190752)
Protein-Protein Interactions		5 interactors: CCR5 CLU DCD IL20RA RARG	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		11009	1234
HPRD ID		04995	03223
Ensembl ID		ENSG00000162892	ENSG00000160791
Uniprot IDs		Q13007	A0A502 P51681 Q38L21
PDB IDs			1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Response To Other Organism Response To Biotic Stimulus Growth Plate Cartilage Chondrocyte Growth Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Growth Plate Cartilage Chondrocyte Development Harderian Gland Development Response To Organic Substance Positive Regulation Of Apoptotic Signaling Pathway Central Nervous System Myelin Maintenance Chondrocyte Hypertrophy Growth Plate Cartilage Chondrocyte Differentiation Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Retinal Pigment Epithelium Development Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Defense Response Lacrimal Gland Development Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Regulation Of Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Chondrocyte Development Involved In Endochondral Bone Morphogenesis Regulation Of Cell Death Trachea Cartilage Development Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Lipid Glial Cell Proliferation Response To Misfolded Protein Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Beta-amyloid Formation Growth Plate Cartilage Development Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Response To Bacterium	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?