RAB32 and CHM

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RAB32	CHM
Description		RAB32, member RAS oncogene family	CHM Rab escort protein
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Endomembrane System Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Lumen Vesicle Melanosome Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Mitochondrion Organization Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Endosome To Melanosome Transport Protein Localization To Membrane Phagosome Maturation Melanosome Assembly	Protein Targeting To Membrane Intracellular Protein Transport Small GTPase-mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Leprosy ( 22019778 25642632 27976721) Metabolite levels ( 23823483)	Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)
Interacting Genes		5 interacting genes: CHM DDIT4L LRMDA PPP3R2 PRKAR2A	11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A
Entrez ID		10981	1121
HPRD ID		06700	02312
Ensembl ID		ENSG00000118508	ENSG00000188419
Uniprot IDs		Q13637	A8K545 B4DRL9 P24386
PDB IDs		4CYM 4CZ2 5OEC 5OED 6FF8
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Protein Prenylation Negative Regulation Of Calcium Ion Import Across Plasma Membrane Penetration Of Zona Pellucida Sperm Mitochondrial Sheath Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Protein Serine/threonine Phosphatase Complex Calcineurin Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Protein Kinase A Catalytic Subunit Binding GDP-dissociation Inhibitor Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Melanocyte Differentiation CAMP Binding Pigment Cell Differentiation Positive Regulation Of Calcium Ion Import Negative Regulation Of CAMP/PKA Signal Transduction Calcineurin-mediated Signaling Intracellular Signal Transduction	GTPase Activity GTP Binding Protein Transport Myosin V Binding Establishment Of Protein Localization GTP-dependent Protein Binding GDP Binding Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Vesicle-mediated Transport G Protein Activity Secretory Granule Membrane Antigen Processing And Presentation Endomembrane System Intracellular Protein Transport Phagosome Maturation Endosome Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization Synaptic Vesicle Membrane Intracellular Transport Vesicle Golgi Apparatus Regulation Of Exocytosis Extracellular Exosome Cellular Localization Endosomal Transport Phagocytic Vesicle Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Retrograde Transport, Endosome To Golgi Synaptic Vesicle Recycling Membrane Perinuclear Region Of Cytoplasm Early Endosome To Golgi Transport Cytosolic Transport Synaptic Vesicle Melanosome Membrane Phagophore Assembly Site Membrane Cytoplasmic Vesicle Bone Resorption Vacuole Organization Regulation Of Transport Trans-Golgi Network Exocytosis Early Endosome Membrane Localization Within Membrane Organelle Organization
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