RAB32 and LRMDA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB32	LRMDA
Description		RAB32, member RAS oncogene family	leucine rich melanocyte differentiation associated
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Endomembrane System Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Lumen Vesicle Melanosome Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Intracellular Protein Transport Mitochondrion Organization Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Endosome To Melanosome Transport Protein Localization To Membrane Phagosome Maturation Melanosome Assembly	Cell Differentiation Melanocyte Differentiation
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Leprosy ( 22019778 25642632 27976721) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 33990960) Chronic obstructive pulmonary disease ( 30804561) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Microalbuminuria ( 31511532) Type 2 diabetes ( 32499647) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		5 interacting genes: CHM DDIT4L LRMDA PPP3R2 PRKAR2A	4 interacting genes: AP1M1 EXOSC5 RAB32 RABIF
Entrez ID		10981	83938
HPRD ID		06700	12560
Ensembl ID		ENSG00000118508	ENSG00000148655
Uniprot IDs		Q13637	A0A087WWI0 Q9H2I8
PDB IDs		4CYM 4CZ2 5OEC 5OED 6FF8
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Protein Prenylation Negative Regulation Of Calcium Ion Import Across Plasma Membrane Penetration Of Zona Pellucida Sperm Mitochondrial Sheath Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Protein Serine/threonine Phosphatase Complex Calcineurin Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Protein Kinase A Catalytic Subunit Binding GDP-dissociation Inhibitor Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Melanocyte Differentiation CAMP Binding Pigment Cell Differentiation Positive Regulation Of Calcium Ion Import Negative Regulation Of CAMP/PKA Signal Transduction Calcineurin-mediated Signaling Intracellular Signal Transduction	Endosome To Melanosome Transport Melanosome Assembly Melanosome Organization Pigment Granule Organization BLOC-2 Complex Binding AP-3 Adaptor Complex Binding Vesicle-mediated Transport Protein Transport Early Endosome Lumen AP-1 Adaptor Complex Binding Establishment Of Protein Localization Vesicle Organization Clathrin Adaptor Complex Early Endosome AP-1 Adaptor Complex AP-2 Adaptor Complex Binding Phagosome Maturation Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Intracellular Protein Localization RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Clathrin Adaptor Activity Melanosome Membrane GTP-dependent Protein Binding SnRNA 3'-end Processing Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Platelet Dense Granule Organization Intracellular Protein Transport DNA Modification 3'-5'-RNA Exonuclease Activity SnRNA Processing Clathrin-coated Vesicle Membrane Nuclear RNA Surveillance RNA Surveillance Cytosol Organelle Assembly Organelle Membrane SnRNA Metabolic Process Cytoplasmic Vesicle Euchromatin Secretory Granule Organization
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