PCMT1 and CYSLTR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PCMT1	CYSLTR2
Description		protein-L-isoaspartate (D-aspartate) O-methyltransferase	cysteinyl leukotriene receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Plasma Membrane Membrane
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding	Cysteinyl Leukotriene Receptor Activity G Protein-coupled Receptor Activity Galanin Receptor Activity Leukotriene Receptor Activity Protein Binding
	Biological Process	Protein Methylation Protein Repair Methylation	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		Protein repair	Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events LTC4-CYSLTR mediated IL4 production
Drugs		S-adenosyl-L-homocysteine	Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (MOSTest) ( 32665545)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1	19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE
Entrez ID		5110	57105
HPRD ID		08908	09293
Ensembl ID		ENSG00000120265	ENSG00000152207
Uniprot IDs		A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061	A4ZKH2 Q5KU17 Q9NS75
PDB IDs		1I1N 1KR5
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior	Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway
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