PCMT1 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PCMT1	AGTR1
Description		protein-L-isoaspartate (D-aspartate) O-methyltransferase	angiotensin II receptor type 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Plasma Membrane Membrane
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Methylation Protein Repair Methylation	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Protein repair	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		S-adenosyl-L-homocysteine	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Brain morphology (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (MOSTest) ( 32665545)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		5110	185
HPRD ID		08908	00107
Ensembl ID		ENSG00000120265	ENSG00000144891
Uniprot IDs		A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		1I1N 1KR5	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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