PCMT1

Gene Name		protein-L-isoaspartate (D-aspartate) O-methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity
	Biological Process	Protein Methylation Protein Repair
Pathways
Drugs		S-Adenosyl-L-Homocysteine
Diseases
GWAS
Protein-protein Interactions		7 interactors: AIMP2 APOA1 APOE CHD3 CREBBP RPIA VKORC1
Entrez ID		5110
HPRD ID		08908
Ensembl ID		ENSG00000120265
Uniprot IDs		B7Z972 H7BY58 J3KP72 P22061
PDB IDs		1I1N 1KR5
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Small Molecule Metabolic Process High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Axon Regeneration Anion Homeostasis Neuron Projection Regeneration Regulation Of Plasma Lipoprotein Particle Levels Positive Regulation Of Lipid Biosynthetic Process Cholesterol Transport Sterol Transport Response To Axon Injury Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Negative Regulation Of Inflammatory Response Detection Of Light Stimulus Cholesterol Metabolic Process Lipid Homeostasis Lipoprotein Biosynthetic Process Isoprenoid Metabolic Process Positive Regulation Of Neurofibrillary Tangle Assembly
Tagcloud ?		adaptive adult altered approximate aspartate brains catalyses compensatory extracts glucose gsk3beta hippocampus insulin isoaspartate isoaspartyl juvenile lacking methyltransferase mice mild pdk peak possibly progressive propose testes tolerance transduction upstream