PCMT1 and TAAR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PCMT1	TAAR1
Description		protein-L-isoaspartate (D-aspartate) O-methyltransferase	trace amine associated receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding	Trace-amine Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Amine Receptor Activity
	Biological Process	Protein Methylation Protein Repair Methylation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Protein repair	Amine ligand-binding receptors G alpha (s) signalling events
Drugs		S-adenosyl-L-homocysteine	Amphetamine Lisdexamfetamine Dextroamphetamine Metamfetamine Propylhexedrine SEP-363856
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (MOSTest) ( 32665545)	Compulsion score in obsessive compulsive disorder ( 32063569)
Interacting Genes		15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1	4 interacting genes: GRIK1 PCMT1 RNASEK SVOP
Entrez ID		5110	134864
HPRD ID		08908	18142
Ensembl ID		ENSG00000120265	ENSG00000146399
Uniprot IDs		A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061	Q96RJ0
PDB IDs		1I1N 1KR5	8JLN 8JLO 8JLP 8JLQ 8JLR 8JSO 8UHB 8W87 8W88 8W89 8W8A 8WC8 8WCA 8ZSJ 8ZSP 8ZSS 9JKQ
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior	Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Kainate Selective Glutamate Receptor Complex Transmembrane Transport Kainate Selective Glutamate Receptor Activity Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Repair Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Endocytosis Involved In Viral Entry Into Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Proton-transporting V-type ATPase Complex Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Protein Methylation Lysosomal Lumen Acidification Clathrin-coated Vesicle Membrane RNA Endonuclease Activity Regulation Of Lysosomal Lumen PH Vacuolar Acidification Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Xenobiotic Transport
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