SF3A3 and MIR106B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SF3A3	MIR106B
Description		splicing factor 3a subunit 3	microRNA 106b
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Angiogenesis Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cellular Response To Hypoxia Cellular Response To Amyloid-beta Regulation Of Endothelial Cell Apoptotic Process
Pathways		mRNA Splicing - Major Pathway
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418)
Interacting Genes		38 interacting genes: ADAP1 APBB1 APP CCDC85B HSPB1 MIR106B MIR107 MIR141 MIR145 MIR155 MIR199A1 MIR200A MIR200C MIR206 MIR214 MIR221 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MTNR1B OGT PRPF40A SF3A1 SREK1 TADA2A TCERG1 TRIM69 U2AF1 VAV2 WBP4 ZDHHC17 ZNF212	97 interacting genes: AIMP1 AQR C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FUS G3BP2 GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLRG1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBM10 RBM14 RBM17 RBM4 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYNCRIP TAF15 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		10946	406900
HPRD ID		10411
Ensembl ID		ENSG00000183431	ENSG00000208036
Uniprot IDs		B4DW90 Q12874
PDB IDs		2DT7 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7EVO 7ONB 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Cell Migration MRNA Destabilization Regulation Of Vasculature Development Negative Regulation Of Cytokine Production RNA Destabilization Negative Regulation Of Cell Motility Regulation Of Gene Expression Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Signal Transduction Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of Cell Motility Regulation Of MRNA Stability Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Programmed Cell Death Regulation Of Locomotion Negative Regulation Of Transport Regulation Of RNA Stability Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Spliceosomal Complex Catalytic Step 2 Spliceosome Nucleoplasm Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Nucleus Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Cytoplasmic Stress Granule MiRNA Binding Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability RNA Stabilization TRNA Aminoacylation Negative Regulation Of Translation MRNA Stabilization Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-RNA Complex Assembly Ligase Activity U2 SnRNP Spliceosomal Complex Assembly RNA Helicase Activity Nucleolus Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process Regulation Of Macromolecule Metabolic Process
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