MIR106B and DDX23

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR106B	DDX23
Description		microRNA 106b	DEAD-box helicase 23
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Vesicle	Chromatin Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Chromosome Nucleolus U4/U6 X U5 Tri-snRNP Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Angiogenesis Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cellular Response To Hypoxia Cellular Response To Amyloid-beta Regulation Of Endothelial Cell Apoptotic Process	Cis Assembly Of Pre-catalytic Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing R-loop Processing
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Bipolar disorder ( 21926972)
Interacting Genes		97 interacting genes: AIMP1 AQR C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FUS G3BP2 GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLRG1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBM10 RBM14 RBM17 RBM4 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYNCRIP TAF15 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346	29 interacting genes: CEBPA CLK1 ERG MIR106B MIR128-1 MIR138-2 MIR141 MIR143 MIR19B2 MIR200B MIR200C MIR214 MIR25 MIR363 MIR429 MIR7-1 MIR7-2 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7G MIRLET7I PCM1 RNF10 TERF1 TERF2IP WBP4 WEE2-AS1
Entrez ID		406900	9416
HPRD ID			09908
Ensembl ID		ENSG00000208036	ENSG00000174243
Uniprot IDs			B3KY11 Q9BUQ8
PDB IDs			3JCR 4NHO 6AH0 6QW6 6QX9 8H6E 8H6J 8Q7W 8Q7X 8Q91 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPK 8QXD 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Spliceosomal Complex Catalytic Step 2 Spliceosome Nucleoplasm Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Nucleus Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Cytoplasmic Stress Granule MiRNA Binding Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability RNA Stabilization TRNA Aminoacylation Negative Regulation Of Translation MRNA Stabilization Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-RNA Complex Assembly Ligase Activity U2 SnRNP Spliceosomal Complex Assembly RNA Helicase Activity Nucleolus Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process Regulation Of Macromolecule Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-33 Production Positive Regulation Of Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Translation Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Extracellular Vesicle Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Shelterin Complex Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Extracellular Space Nuclear Telomere Cap Complex Negative Regulation Of Blood Vessel Endothelial Cell Migration
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