SF3A3 and MIR199A1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SF3A3	MIR199A1
Description		splicing factor 3a subunit 3	microRNA 199a-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	Re-entry Into Mitotic Cell Cycle Negative Regulation Of Receptor Internalization Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of TOR Signaling Negative Regulation Of Hepatocyte Growth Factor Production MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Myoblast Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of SMAD Protein Signal Transduction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Lung Blood Pressure Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Connective Tissue Replacement Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Myoblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		mRNA Splicing - Major Pathway
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418)
Interacting Genes		38 interacting genes: ADAP1 APBB1 APP CCDC85B HSPB1 MIR106B MIR107 MIR141 MIR145 MIR155 MIR199A1 MIR200A MIR200C MIR206 MIR214 MIR221 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MTNR1B OGT PRPF40A SF3A1 SREK1 TADA2A TCERG1 TRIM69 U2AF1 VAV2 WBP4 ZDHHC17 ZNF212	83 interacting genes: AIMP1 AIMP2 C1QBP CELF1 CELF2 CPSF1 CPSF6 CPSF7 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SAFB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SYMPK SYNCRIP TAF15 TIAL1 TRA2A TRA2B UPF1 UTP20 YBX1 YBX2 YBX3
Entrez ID		10946	406976
HPRD ID		10411
Ensembl ID		ENSG00000183431	ENSG00000207752
Uniprot IDs		B4DW90 Q12874
PDB IDs		2DT7 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7EVO 7ONB 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Cell Migration MRNA Destabilization Regulation Of Vasculature Development Negative Regulation Of Cytokine Production RNA Destabilization Negative Regulation Of Cell Motility Regulation Of Gene Expression Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Signal Transduction Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of Cell Motility Regulation Of MRNA Stability Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Programmed Cell Death Regulation Of Locomotion Negative Regulation Of Transport Regulation Of RNA Stability Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing MRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Nucleus Ribonucleoprotein Complex Nucleoplasm MRNA 3'-UTR Binding Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Catalytic Step 2 Spliceosome Spliceosomal Complex MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation TRNA Aminoacylation Regulation Of MRNA Stability Regulation Of Primary Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Metabolic Process Ligase Activity MRNA Stabilization Regulation Of RNA Metabolic Process TRNA Metabolic Process Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation
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