SRSF8 and EIF4ENIF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF8	EIF4ENIF1
Description		serine and arginine rich splicing factor 8	eukaryotic translation initiation factor 4E nuclear import factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Chronic widespread musculoskeletal pain ( 33331911)	Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		24 interacting genes: APP CLK1 CLK2 CLK3 EIF4ENIF1 FOXP1 H19 KRTAP12-2 LUC7L LUC7L2 NXF1 PRPF38A PRPF6 RBM26 SNRNP48 SNRPA SREK1 SRPK1 SRPK2 SRSF3 ST13 TRA2B UBC WDR83	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		10929	56478
HPRD ID		04466	10456
Ensembl ID		ENSG00000263465	ENSG00000184708
Uniprot IDs		Q9BRL6	Q9NRA8
PDB IDs		2DNM	5ANR 6F9W 6X2R
Enriched GO Terms of Interacting Partners?		RNA Splicing Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Spliceosomal Complex RNA Processing MRNA Binding U1 SnRNP Nucleus Protein Serine/threonine/tyrosine Kinase Activity RNA Metabolic Process MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleoplasm Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Nucleic Acid Metabolic Process U2-type Prespliceosome Pre-mRNA Binding Macromolecule Metabolic Process Protein Kinase Activity Protein Tyrosine Kinase Activity Nuclear Export Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Kinase Activity Protein Phosphorylation Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Phosphorylation Identical Protein Binding Negative Regulation Of Viral Genome Replication U2-type Precatalytic Spliceosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity
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