SRSF8 and ST13

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF8	ST13
Description		serine and arginine rich splicing factor 8	ST13 Hsp70 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity Protein Dimerization Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Protein Folding Response To Bacterium
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Chronic widespread musculoskeletal pain ( 33331911)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Feeling nervous ( 29500382) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: APP CLK1 CLK2 CLK3 EIF4ENIF1 FOXP1 H19 KRTAP12-2 LUC7L LUC7L2 NXF1 PRPF38A PRPF6 RBM26 SNRNP48 SNRPA SREK1 SRPK1 SRPK2 SRSF3 ST13 TRA2B UBC WDR83	25 interacting genes: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 GRIK1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 NOS3 OGT OLFM2 PSEN1 PTGER4 RBFOX2 SMAD2 SNCA SRSF8 TTR VAV2
Entrez ID		10929	6767
HPRD ID		04466	08426
Ensembl ID		ENSG00000263465	ENSG00000100380
Uniprot IDs		Q9BRL6	A0A140VKA6 B4E0U6 P50502 Q0IJ56
PDB IDs		2DNM
Enriched GO Terms of Interacting Partners?		RNA Splicing Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Spliceosomal Complex RNA Processing MRNA Binding U1 SnRNP Nucleus Protein Serine/threonine/tyrosine Kinase Activity RNA Metabolic Process MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleoplasm Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Nucleic Acid Metabolic Process U2-type Prespliceosome Pre-mRNA Binding Macromolecule Metabolic Process Protein Kinase Activity Protein Tyrosine Kinase Activity Nuclear Export Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Kinase Activity Protein Phosphorylation Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Phosphorylation Identical Protein Binding Negative Regulation Of Viral Genome Replication U2-type Precatalytic Spliceosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import	ATP-dependent Protein Folding Chaperone Protein-containing Complex Regulation Of Protein-containing Complex Assembly Blood Microparticle C3HC4-type RING Finger Domain Binding Regulation Of Biological Quality Regulation Of Supramolecular Fiber Organization ATP-dependent Protein Disaggregase Activity Protein Refolding Negative Regulation Of Cellular Component Organization Tau Protein Binding Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Protein Folding Chaperone Intracellular Signal Transduction Negative Regulation Of Platelet Activation Inclusion Body Response To Stress Regulation Of Inclusion Body Assembly Positive Regulation Of Supramolecular Fiber Organization Chaperone-mediated Protein Complex Assembly Signal Transduction Disordered Domain Specific Binding Response To Unfolded Protein Response To Heat Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein Folding Positive Regulation Of Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Proteolysis Aggresome Negative Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Unfolded Protein Binding Response To Hormone Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Receptor Ligand Activity Regulation Of Immune System Process Chaperone-mediated Autophagy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cellular Response To Heat Positive Regulation Of Microtubule Nucleation
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