SRSF8 and SNRNP48

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF8	SNRNP48
Description		serine and arginine rich splicing factor 8	small nuclear ribonucleoprotein U11/U12 subunit 48
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Chronic widespread musculoskeletal pain ( 33331911)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Height ( 31562340) Obesity-related traits ( 23251661)
Interacting Genes		24 interacting genes: APP CLK1 CLK2 CLK3 EIF4ENIF1 FOXP1 H19 KRTAP12-2 LUC7L LUC7L2 NXF1 PRPF38A PRPF6 RBM26 SNRNP48 SNRPA SREK1 SRPK1 SRPK2 SRSF3 ST13 TRA2B UBC WDR83	14 interacting genes: CDCA7L ENKD1 EXOSC7 GPX4 GRN HUNK LUC7L2 MRPS27 PRPF6 SRSF8 SUPT5H TFIP11 UBASH3A UTP14A
Entrez ID		10929	154007
HPRD ID		04466	12858
Ensembl ID		ENSG00000263465	ENSG00000168566
Uniprot IDs		Q9BRL6	Q6IEG0
PDB IDs		2DNM	2VY4 2VY5 8R7N 8Y6O 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		RNA Splicing Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Spliceosomal Complex RNA Processing MRNA Binding U1 SnRNP Nucleus Protein Serine/threonine/tyrosine Kinase Activity RNA Metabolic Process MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleoplasm Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Nucleic Acid Metabolic Process U2-type Prespliceosome Pre-mRNA Binding Macromolecule Metabolic Process Protein Kinase Activity Protein Tyrosine Kinase Activity Nuclear Export Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Kinase Activity Protein Phosphorylation Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Phosphorylation Identical Protein Binding Negative Regulation Of Viral Genome Replication U2-type Precatalytic Spliceosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import	RNA Binding Nuclear Speck
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