PDIA4 and APOB

Number of citations of the paper that reports this interaction (PubMedID 12397072)
0

Data Source:
HPRD (in vitro, in vivo)

		PDIA4	APOB
Description		protein disulfide isomerase family A member 4	apolipoprotein B
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cell Surface Melanosome	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Isomerase Activity	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Protein Folding Protein Secretion Response To Endoplasmic Reticulum Stress	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways			Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Height ( 20881960) Waist circumference adjusted for body mass index ( 34021172)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Non-HDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817) Triglyceride levels ( 29403010 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806)
Interacting Genes		7 interacting genes: APOB BCL2L1 CEBPA GADD45G KRTAP10-8 KRTAP12-1 LCN2	25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2
Entrez ID		9601	338
HPRD ID		06501	00133
Ensembl ID		ENSG00000155660	ENSG00000084674
Uniprot IDs		A0A090N8Y2 A0A499FI48 P13667	A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0
PDB IDs		3IDV	9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG
Enriched GO Terms of Interacting Partners?		Mature Chylomicron Sterol Metabolic Process Response To Virus Cholesterol Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Chylomicron Remnant Positive Regulation Of Programmed Cell Death Response To Amino Acid Extrinsic Apoptotic Signaling Pathway Response To Peptide Positive Regulation Of Apoptotic Process Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Response To Cytokine Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Ionizing Radiation Apoptotic Process In Bone Marrow Cell Acute-phase Response CHOP-C/EBP Complex Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 Memory C/EBP Complex Acute Inflammatory Response Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Positive Regulation Of Cold-induced Thermogenesis Keratin Filament Fertilization Triglyceride Mobilization Response To Ionizing Radiation White Fat Cell Proliferation Cytoplasmic Vesicle Lumen Regulation Of Cold-induced Thermogenesis Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Lipid Homeostasis Intermediate-density Lipoprotein Particle Response To Cycloheximide Cellular Response To Radiation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death
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