NPFFR2 and TMEM218

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NPFFR2	TMEM218
Description		neuropeptide FF receptor 2	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Membrane	Cilium Membrane Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Opioid Receptor Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS			Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1	75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		10886	219854
HPRD ID		16244	19054
Ensembl ID		ENSG00000056291	ENSG00000150433
Uniprot IDs		A0A804CC06 A0PJM9 Q9Y5X5	A2RU14 E9PI23
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Hormone Activity Neuropeptide Signaling Pathway Regulation Of Response To Food Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Response To Nutrient Levels Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Regulation Of Neurotransmitter Secretion Feeding Behavior Type 2 Orexin Receptor Binding G Protein-coupled Receptor Binding Short-day Photoperiodism Regulation Of Postsynaptic Membrane Potential Regulation Of Secretion By Cell Regulation Of Nerve Growth Factor Production Neuropeptide Activity Somatostatin Secretion Cell-cell Signaling Cell Communication Regulation Of Secretion Signaling Neuropeptide Y Receptor Binding Perikaryon Vasopressin Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Perinuclear Region Of Cytoplasm Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Lumen Negative Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Positive Regulation Of Transmission Of Nerve Impulse Sleep Postsynapse Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Adult Feeding Behavior FK506 Binding Antifungal Humoral Response Intestinal Epithelial Cell Differentiation	Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid
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