NPFFR2 and NPY

Number of citations of the paper that reports this interaction (PubMedID 12609745)
0

Data Source:
HPRD (in vivo)

		NPFFR2	NPY
Description		neuropeptide FF receptor 2	neuropeptide Y
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Membrane	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Opioid Receptor Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS			Adiponectin levels ( 33562295) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Retinitis pigmentosa ( 33514863) Vitamin D levels ( 25208829)
Interacting Genes		6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		10886	4852
HPRD ID		16244	01214
Ensembl ID		ENSG00000056291	ENSG00000122585
Uniprot IDs		A0A804CC06 A0PJM9 Q9Y5X5	A4D158 P01303
PDB IDs			1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O
Enriched GO Terms of Interacting Partners?		Neuropeptide Hormone Activity Neuropeptide Signaling Pathway Regulation Of Response To Food Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Response To Nutrient Levels Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Regulation Of Neurotransmitter Secretion Feeding Behavior Type 2 Orexin Receptor Binding G Protein-coupled Receptor Binding Short-day Photoperiodism Regulation Of Postsynaptic Membrane Potential Regulation Of Secretion By Cell Regulation Of Nerve Growth Factor Production Neuropeptide Activity Somatostatin Secretion Cell-cell Signaling Cell Communication Regulation Of Secretion Signaling Neuropeptide Y Receptor Binding Perikaryon Vasopressin Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Perinuclear Region Of Cytoplasm Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Lumen Negative Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Positive Regulation Of Transmission Of Nerve Impulse Sleep Postsynapse Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Adult Feeding Behavior FK506 Binding Antifungal Humoral Response Intestinal Epithelial Cell Differentiation	Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport
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