NPFFR2 and NPY

Number of citations of the paper that reports this interaction (PMID 12609745)
0

Data Source:
HPRD (in vivo)

		NPFFR2	NPY
Gene Name		neuropeptide FF receptor 2	neuropeptide Y
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton	Extracellular Region Extracellular Space Cell Golgi Apparatus
	Molecular Function	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding	G-protein Coupled Receptor Activity Receptor Binding Neuropeptide Hormone Activity Calcium Channel Regulator Activity Neuropeptide Y Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Response To Peptide Regulation Of CAMP-dependent Protein Kinase Activity	Calcium Ion Transport Movement Of Cell Or Subcellular Component G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Digestion Behavior Feeding Behavior Blood Circulation Regulation Of Blood Pressure Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Regulation Of Appetite Positive Regulation Of Appetite
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Periodontitis ( 23459936)
Protein-Protein Interactions		3 interactors: HCRT NPFF NPY	15 interactors: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1
Entrez ID		10886	4852
HPRD ID		16244	01214
Ensembl ID		ENSG00000056291	ENSG00000122585
Uniprot IDs		A0PJM9 Q9Y5X5	A4D158 P01303
PDB IDs			1QFA 1RON
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Regulation Of Response To Food Regulation Of Appetite Synaptic Transmission Regulation Of Neurological System Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Feeding Behavior Cell-cell Signaling Membrane Depolarization G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Somatostatin Secretion Vasopressin Secretion Regulation Of Membrane Potential Cellular Calcium Ion Homeostasis Negative Regulation Of Transmission Of Nerve Impulse Calcium Ion Homeostasis Blood Circulation Positive Regulation Of Appetite Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Transmission Of Nerve Impulse Response To Nutrient Levels Cellular Cation Homeostasis Cellular Ion Homeostasis Acute Inflammatory Response To Antigenic Stimulus Response To Extracellular Stimulus Metal Ion Homeostasis Negative Regulation Of Heart Rate Adult Feeding Behavior Negative Regulation Of Appetite Regulation Of Transmission Of Nerve Impulse Cellular Chemical Homeostasis Ion Homeostasis Negative Regulation Of Neurological System Process Behavior Regulation Of Secretion Cell Surface Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Negative Regulation Of Heart Contraction Regulation Of Sensory Perception Of Pain Eating Behavior Chemical Homeostasis Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Blood Pressure	Neuropeptide Signaling Pathway Feeding Behavior Cell-cell Signaling Synaptic Transmission G-protein Coupled Receptor Signaling Pathway Behavior Digestion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Transport Negative Regulation Of Secretion Negative Regulation Of Feeding Behavior Outflow Tract Morphogenesis Peptide Hormone Secretion Peptide Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Hormone Secretion Regulation Of CAMP Biosynthetic Process Hormone Transport Cell Surface Receptor Signaling Pathway Peptide Transport Signal Transduction Regulation Of Secretion Regulation Of CAMP Metabolic Process Regulation Of Feeding Behavior Cellular Response To Stimulus Cardiac Left Ventricle Morphogenesis Response To Stimulus Membrane Depolarization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Response To Food Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Positive Regulation Of Circadian Rhythm Amide Transport Regulation Of Appetite Cell Communication Multicellular Organismal Reproductive Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organism Reproduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Chemical Homeostasis Negative Regulation Of Secretion By Cell Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Negative Regulation Of Insulin Secretion Regulation Of Cellular Localization
Tagcloud ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular
Tagcloud (Difference) ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt nfatc1 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally pflugers ramiprilat renovascular tubular
Tagcloud (Intersection) ?		neuropeptide