NPFFR2 and HCRT

Number of citations of the paper that reports this interaction (PMID 12609745)
0

Data Source:
HPRD (in vivo)

		NPFFR2	HCRT
Gene Name		neuropeptide FF receptor 2	hypocretin (orexin) neuropeptide precursor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Cell Junction Secretory Granule Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding	Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Response To Peptide Regulation Of CAMP-dependent Protein Kinase Activity	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of DNA Replication Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: HCRT NPFF NPY	3 interactors: HCRTR1 HCRTR2 NPFFR2
Entrez ID		10886	3060
HPRD ID		16244	03836
Ensembl ID		ENSG00000056291	ENSG00000161610
Uniprot IDs		A0PJM9 Q9Y5X5	O43612
PDB IDs			1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Regulation Of Response To Food Regulation Of Appetite Synaptic Transmission Regulation Of Neurological System Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Feeding Behavior Cell-cell Signaling Membrane Depolarization G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Somatostatin Secretion Vasopressin Secretion Regulation Of Membrane Potential Cellular Calcium Ion Homeostasis Negative Regulation Of Transmission Of Nerve Impulse Calcium Ion Homeostasis Blood Circulation Positive Regulation Of Appetite Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Transmission Of Nerve Impulse Response To Nutrient Levels Cellular Cation Homeostasis Cellular Ion Homeostasis Acute Inflammatory Response To Antigenic Stimulus Response To Extracellular Stimulus Metal Ion Homeostasis Negative Regulation Of Heart Rate Adult Feeding Behavior Negative Regulation Of Appetite Regulation Of Transmission Of Nerve Impulse Cellular Chemical Homeostasis Ion Homeostasis Negative Regulation Of Neurological System Process Behavior Regulation Of Secretion Cell Surface Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Negative Regulation Of Heart Contraction Regulation Of Sensory Perception Of Pain Eating Behavior Chemical Homeostasis Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Blood Pressure	Neuropeptide Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Regulation Of Circadian Rhythm Feeding Behavior Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Regulation Of Behavior Cellular Response To Organic Substance Circadian Sleep/wake Cycle Process Circadian Sleep/wake Cycle Response To Organic Substance Regulation Of CAMP-dependent Protein Kinase Activity Behavior Circadian Behavior Cell Surface Receptor Signaling Pathway Rhythmic Behavior Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Signal Transduction Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Signaling Cell Communication Circadian Rhythm Cellular Response To Stimulus Detection Of Abiotic Stimulus
Tagcloud ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Difference) ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Intersection) ?