FAM114A2 and GAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM114A2	GAD2
Description		family with sequence similarity 114 member A2	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component		Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding Purine Nucleotide Binding	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process		Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process
Pathways		Signaling by BRAF and RAF1 fusions	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Red cell distribution width ( 28957414 32888494)	Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		11 interacting genes: APP GAD2 MIEF2 NDUFV2 PILRA PTPN9 RAB2A RAB2B SH3GLB1 TBRG4 TTPA	48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33
Entrez ID		10827	2572
HPRD ID		12831	11817
Ensembl ID		ENSG00000055147	ENSG00000136750
Uniprot IDs		A0A140VKG4 B3KTE4 B4DQT0 E7ESJ7 I6L9D5 Q9NRY5	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK 7LZ6
Enriched GO Terms of Interacting Partners?		Autophagosome Membrane Regulation Of Amyloid-beta Clearance Cytoplasmic Vesicle Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Golgi Membrane Negative Regulation Of Establishment Of Blood-brain Barrier Mitochondrial MRNA Processing Protein Localization To Vacuolar Membrane Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Establishment Of Protein Localization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Apparatus Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Autophagy Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Positive Regulation Of Membrane Tubulation	Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport
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