FAM114A2 and NDUFV2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM114A2	NDUFV2
Description		family with sequence similarity 114 member A2	NADH:ubiquinone oxidoreductase core subunit V2
Image		No pdb structure
GO Annotations	Cellular Component		Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding Purine Nucleotide Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process		Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Cardiac Muscle Tissue Development Proton Transmembrane Transport
Pathways		Signaling by BRAF and RAF1 fusions	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Red cell distribution width ( 28957414 32888494)	Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Platelet distribution width ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: APP GAD2 MIEF2 NDUFV2 PILRA PTPN9 RAB2A RAB2B SH3GLB1 TBRG4 TTPA	5 interacting genes: CRMP1 FAM114A2 GOLM1 KAT5 SP110
Entrez ID		10827	4729
HPRD ID		12831	02757
Ensembl ID		ENSG00000055147	ENSG00000178127
Uniprot IDs		A0A140VKG4 B3KTE4 B4DQT0 E7ESJ7 I6L9D5 Q9NRY5	P19404
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Autophagosome Membrane Regulation Of Amyloid-beta Clearance Cytoplasmic Vesicle Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Golgi Membrane Negative Regulation Of Establishment Of Blood-brain Barrier Mitochondrial MRNA Processing Protein Localization To Vacuolar Membrane Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Establishment Of Protein Localization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Apparatus Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Autophagy Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Positive Regulation Of Membrane Tubulation	Pyrimidine-containing Compound Metabolic Process Nuclear Lumen Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Histone H2AK5 Acetyltransferase Activity
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