GAD2 and RHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAD2	RHEX
Description		glutamate decarboxylase 2	regulator of hemoglobinization and erythroid cell expansion
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Plasma Membrane Membrane
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Erythropoietin Receptor Binding Protein Binding
	Biological Process	Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process	Cell Differentiation Cellular Response To Erythropoietin Erythropoietin-mediated Signaling Pathway Erythrocyte Maturation Positive Regulation Of Erythrocyte Differentiation
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33	7 interacting genes: GAD2 GET3 PBX3 RBFA SH3GL1 SH3GLB1 SNX1
Entrez ID		2572	440712
HPRD ID		11817	17400
Ensembl ID		ENSG00000136750	ENSG00000263961
Uniprot IDs		Q05329 Q5VZ30	Q6ZWK4
PDB IDs		1ES0 2OKK 7LZ6
Enriched GO Terms of Interacting Partners?		Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport	Posterior Compartment Specification Anterior Compartment Pattern Formation Lipid Binding Cadherin Binding Protein Localization To Vacuolar Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity GET Complex Compartment Pattern Specification Retromer, Tubulation Complex Leptin Receptor Binding 'de Novo' Post-translational Protein Folding Positive Regulation Of Membrane Tubulation Dorsal Spinal Cord Development Autophagic Cell Death Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Early Endosome Membrane Lamellipodium Morphogenesis Phosphatidylinositol 3-kinase Activator Activity Carbon-carbon Lyase Activity 'de Novo' Protein Folding
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