GAD2 and ARMC12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAD2	ARMC12
Description		glutamate decarboxylase 2	armadillo repeat containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Protein Binding
	Biological Process	Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process	Spermatogenesis Cell Differentiation Positive Regulation Of Cell Growth Flagellated Sperm Motility Sperm Mitochondrial Sheath Assembly
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)	Depression x herpes simplex 1 infection interaction ( 32564518) Eosinophil percentage of granulocytes ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33	8 interacting genes: EHHADH FA2H GAD2 RBBP4 SENP2 SNX1 SPG21 TTPA
Entrez ID		2572	221481
HPRD ID		11817	12901
Ensembl ID		ENSG00000136750	ENSG00000157343
Uniprot IDs		Q05329 Q5VZ30	Q5T9G4
PDB IDs		1ES0 2OKK 7LZ6
Enriched GO Terms of Interacting Partners?		Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport	Small Molecule Biosynthetic Process Carboxylic Acid Biosynthetic Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Negative Regulation Of Establishment Of Blood-brain Barrier Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Monocarboxylic Acid Metabolic Process Fatty Acid Biosynthetic Process CAF-1 Complex Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Central Nervous System Myelin Maintenance Organic Acid Metabolic Process Lyase Activity Carboxylic Acid Metabolic Process Lipid Modification Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Cytosol Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane DNA Replication-dependent Chromatin Assembly NURF Complex Retromer, Tubulation Complex Lamellipodium Morphogenesis Leptin Receptor Binding Vitamin E Metabolic Process Positive Regulation Of Amyloid-beta Clearance SUMO-specific Endopeptidase Activity DeSUMOylase Activity Regulation Of DNA Endoreduplication Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Peripheral Nervous System Myelin Maintenance Carboxylic Acid Catabolic Process Carbon-carbon Lyase Activity
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