GAD2 and DMKN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAD2	DMKN
Description		glutamate decarboxylase 2	dermokine
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Extracellular Region Extracellular Space
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Protein Binding
	Biological Process	Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process	Cornified Envelope Assembly
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33	7 interacting genes: APP BAG6 GAD2 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		2572	93099
HPRD ID		11817	12387
Ensembl ID		ENSG00000136750	ENSG00000161249
Uniprot IDs		Q05329 Q5VZ30	A3EZ84 C9IYI1 C9J186 C9JCN1 E9PAQ7 M0R0A5 M0R3F8 Q6E0U4
PDB IDs		1ES0 2OKK 7LZ6	4F20
Enriched GO Terms of Interacting Partners?		Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport	Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis TRC Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Polyubiquitin Modification-dependent Protein Binding Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Identical Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Proteasomal Protein Catabolic Process Molecular Adaptor Activity Protein Catabolic Process Establishment Of Protein Localization To Membrane Protein Targeting Protein Insertion Into ER Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Hsp70 Protein Binding Cytoplasmic Vesicle Establishment Of Protein Localization To Organelle Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Insertion Into Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor Internalization Macromolecule Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Autophagosome Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?