TTYH1

Description		tweety family member 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Smooth Endoplasmic Reticulum Membrane Filopodium Membrane Filopodium Tip Chloride Channel Complex Synapse
	Molecular Function	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Iron Ion Transmembrane Transporter Activity Calcium Ion Binding Protein Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Mitotic Cell Cycle Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Iron Ion Transport Cell Adhesion Notch Signaling Pathway Gene Expression L-glutamate Transmembrane Transport Neurogenesis Cell-substrate Adhesion Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Filopodium Assembly Stem Cell Differentiation Stem Cell Proliferation Cell-cell Adhesion Chloride Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Idiopathic pulmonary fibrosis ( 29066090)
Novel Interacting Genes		1 novel interacting genes: USP54
Interacting Genes		6 interacting genes: CCR9 DRD2 DSCR9 GPR37 HTR6 TMEM60
Entrez ID		57348
HPRD ID		12043
Ensembl ID		ENSG00000167614
Uniprot IDs		Q9H313
PDB IDs		7P5J
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway Forebrain Cell Migration Catecholamine Metabolic Process Dopamine Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Biogenic Amine Metabolic Process Amine Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Dendrite G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Prosaposin Receptor Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Dopamine Metabolic Process Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Catecholamine Uptake Dopamine Uptake
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