DNAAF5 and OTUD4

		DNAAF5	OTUD4
Description		dynein axonemal assembly factor 5	OTU deubiquitinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Cytoskeleton Motile Cilium Mitotic Spindle Dynein Axonemal Particle	Nucleus Cytoplasm Cytosol
	Molecular Function	Dynein Intermediate Chain Binding	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Molecular Adaptor Activity K63-linked Deubiquitinase Activity
	Biological Process	Cilium Movement Cell Projection Organization Outer Dynein Arm Assembly Inner Dynein Arm Assembly	Immune System Process DNA Alkylation Repair Proteolysis Negative Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Deubiquitination Protein K27-linked Ubiquitination Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Initial pursuit acceleration ( 29064472) Retinitis pigmentosa ( 33514863)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: FEZ1 PFKL USP39 WEE2-AS1 ZBTB16	12 interacting genes: ALKBH3 EXOSC8 MAVS PFKFB3 REL STAT1 TCF4 UBC USP7 VDR ZBTB7A ZNF655
Entrez ID		54919	54726
HPRD ID		07903	11033
Ensembl ID		ENSG00000164818	ENSG00000164164
Uniprot IDs		B3KPE2 Q86Y56	Q01804
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Interferon-alpha Production Histone Acetyltransferase Binding DNA Alkylation Repair Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Interferon-beta Production Brain Renin-angiotensin System TORC1 Signaling Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Transcription Corepressor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding MRNA Transcription Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Lithocholic Acid Binding Regulation Of Peroxisome Organization Positive Regulation Of IP-10 Production MRNA N1-methyladenosine Dioxygenase Activity Nucleobase-containing Compound Metabolic Process Nucleoplasm 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II NF-kappaB Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Metabolic Process
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