DNAAF5 and MMP16

		DNAAF5	MMP16
Description		dynein axonemal assembly factor 5	matrix metallopeptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Cytoskeleton Motile Cilium Mitotic Spindle Dynein Axonemal Particle	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix
	Molecular Function	Dynein Intermediate Chain Binding	Metalloendopeptidase Activity Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Cilium Movement Cell Projection Organization Outer Dynein Arm Assembly Inner Dynein Arm Assembly	Skeletal System Development Ossification Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Bone Development Craniofacial Suture Morphogenesis
Pathways			Activation of Matrix Metalloproteinases TGFBR3 PTM regulation
Drugs			Marimastat Batimastat
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Initial pursuit acceleration ( 29064472) Retinitis pigmentosa ( 33514863)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 21926974 28991256 25056061 23974872 22688191) Sweet taste perception in obesity with metabolic syndrome ( 31005965) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: FEZ1 PFKL USP39 WEE2-AS1 ZBTB16	2 interacting genes: KISS1 LRP1
Entrez ID		54919	4325
HPRD ID		07903	03776
Ensembl ID		ENSG00000164818	ENSG00000156103
Uniprot IDs		B3KPE2 Q86Y56	P51512
PDB IDs			1RM8
Enriched GO Terms of Interacting Partners?			Kisspeptin Receptor Binding Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity 2,4-dienoyl-CoA Reductase (NADPH) Activity Lipid Modification Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Positive Regulation Of Luteinizing Hormone Secretion Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Lipid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Regulation Of Endocytosis NADPH Binding Lipoprotein Transport Lysosomal Membrane Plasma Membrane Protein Complex Astrocyte Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Dynein Axonemal Particle Inner Dynein Arm Assembly Transcytosis Outer Dynein Arm Assembly Regulation Of Amyloid-beta Clearance Catalytic Complex Regulation Of Transport Cargo Receptor Activity Aorta Morphogenesis Regulation Of Extracellular Matrix Disassembly Amyloid-beta Metabolic Process Scavenger Receptor Activity Apoptotic Cell Clearance Phosphatidylinositol Dephosphorylation Negative Regulation Of Phagocytosis Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process
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